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KMID : 1161420190220010029
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Journal of Medicinal Food
2019 Volume.22 No. 1 p.29 ~ p.37
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Maoberry (Antidesma bunius) Improves Glucose Metabolism, Triglyceride Levels, and Splenic Lesions in High-Fat Diet-Induced Hypercholesterolemic Rats
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Udomkasemsab Arunwan
Ngamlerst Chattraya
Kwanbunjun Karunee
Krasae Thanyaluk
Amnuaysookkasem Krieangsak
Chunthanom Pornprapha
Prangthip Pattaneeya
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Abstract
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Excessive consumption of a high-fat diet (HFD) is associated with hypercholesterolemia and cardiovascular disease (CVD). Dark purple maoberry (Antidesma bunius) fruit is a very good source of antioxidants. We investigated the effects of maoberry on immune function, lipid profiles, and oxidative stress in HFD-induced hypercholesterolemia. Seventy-two male Sprague Dawley rats were divided into the normal group fed with standard diet (ND); HFD groups (HF); and low, medium, and high dose of maoberry extract groups and a simvastatin group (HF-L, HF-M, HF-H, and HF-S, respectively). Maoberry groups were given maoberry extract at concentrations of 0.38, 0.76, and 1.52?g/kg per day. At the same time, HF-S groups were administered simvastatin 10?mg/kg per day. After 12 weeks of maoberry treatment, significant reductions in body weight and triglyceride levels were observed in HF-L, HF-M, and HF-H groups in comparison with HF groups (P?
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KEYWORD
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Antidesma bunius, glucose, high-fat diet, maoberry, triglyceride
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